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β-GalNAc-Hexanoic acid (Peracetate)
the sialylation of therapeutic proteins can affect their serum half-life
followed by cleavage of the α-glycosidic bond by α-L-iduronidase (IDUA) to release 4-methylumbelliferone
/ CMP-N-acetylneuraminic acid / CMP-Neu5Ac
2-Azidoethyl 2-(Acetylamino)-2-deoxy-α-D-galactopyranoside
AG152015: β-D-GalNAc-Pentyl-Carboxylic Acid (Peracetate) Pack Size:25 mg β-GalNAc-Hexanoic acid (Peracetate)C20H31NO11 461. 46 A peracetylated D N acetylgalactosamine (GalNAc) ligand equipped with a terminal carboxylic acid through a pentyl spacer, with the sugar hydroxyl groups protected as acetate esters. The peracetate groups increase lipophilicity to facilitate cell membrane permeability. The carboxylic acid can be activated to NHS, sulfo NHS, or pentafluorophenyl (PFP) esters and reacted with amine functionalized platforms or lysine residues on
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